ArticleNeurobiology of pain (Cambridge, Mass.)
Paclitaxel induced-mechanical hypersensitivity is associated with time-dependant pro-inflammatory galectin-3
Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain is a dose-limiting side effect of chemotherapeutic agents such as paclitaxel, and it is unsuccessfully treated by available analgesics. Among the mechanisms underlying paclitaxel-induced neuropathic pain, neuroimmune interactions in the dorsal root ganglia (DRGs) play a pronociceptive role. However, how immune responses evolve over time during pain maintenance and persistence is poorly understood. Here we treated mice with six injections of paclitaxel (PTX) every other day over 10 days (cumulative dose of 15 mg/kg) and detected mechanical hypersensitivity that developed at day 7 and lasted up to day 28 after first PTX injection. We observed a time-dependent accumulation of macrophages in lumbar DRGs at day 28, but not day 14 after first PTX injection. At day 28, proinflammatory macrophages MHCII
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.