A case report of hyponatremia induced by hypopituitarism following severe traumatic brain injury and literature review.

Dan-Dan Liu, Shan-Shan Xu, Xu An, Yue-Fu Wang, Jian-Xin Zhou

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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5 authors.

Dan-Dan LiuDepartment of Surgical Intensive Care Unit, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Shan-Shan XuEmergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Xu AnEmergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Yue-Fu WangDepartment of Surgical Intensive Care Unit, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Jian-Xin ZhouEmergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyponatremia induced by hypopituitarism is an underrecognized complication in neurocritical care settings. This article presents a case of a patient with severe traumatic brain injury who developed euvolemic hyponatremia one month after the injury, accompanied by decreased serum osmolality. The hyponatremia remained refractory to conventional management, including fluid restriction and hypertonic saline supplementation. Subsequent endocrine evaluation confirmed hypopituitarism, characterized by markedly suppressed ACTH (<1 pg/ml) and low morning cortisol (1.68 μg/dl). Notably, serum sodium levels normalized following the initiation of exogenous hormone replacement. Our findings may represent an important but underrecognized cause of hyponatremia in neurocritical care patients, particularly those with severe acute brain injuries. Comprehensive testing for neuroendocrine hormones in this subset of patients is beneficial.

Indexed as

cerebral salt wasting syndromehyponatremiahypopituitarisminappropriate antidiuretic hormone secretionneurocritical care

Identifiers

PMID42292251

DOI10.3389/fmed.2026.1847538

PMCPMC13260307

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