ArticleFrontiers in medicine2026
Correlation between tumor mutational burden and CT radiographic features in EGFR exon 19 deletion-mutated lung adenocarcinoma: a diagnostic accuracy study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: As the predominant subtype of non-small cell lung cancer, lung adenocarcinoma exhibits a pathogenesis closely associated with molecular characteristics. Tumor mutational burden (TMB) has emerged as a critical biomarker for predicting responses to immunotherapy. Although computed tomography (CT) imaging is widely utilized in diagnosing lung adenocarcinoma and its morphological features may reflect genomic attributes, the precise relationship between TMB and CT radiographic features remains inadequately elucidated. Objective: This study aimed to investigate the correlation between TMB and CT radiographic features in lung adenocarcinoma and to evaluate the diagnostic value of these features in identifying high TMB, thereby providing a non-invasive approach for TMB assessment. Methods: A total of 156 treatment-naïve lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) exon 19 deletion mutations, admitted to Funan County People's Hospital between January 2022 and August 2025, were enrolled. Based on TMB levels, patients were stratified into high-TMB (TMB ≥ 10 mut/Mb, Results: The high-TMB group exhibited a significantly larger maximum tumor diameter compared to the low-TMB group ( Conclusion: CT-based radiological features are significantly correlated with TMB status in lung adenocarcinoma. A composite model incorporating these features demonstrates high diagnostic accuracy for identifying high TMB, offering a valuable non-invasive tool for guiding personalized treatment strategies.
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