SynthesisFrontiers in medicine2026
Aesthetic techniques for melanocytic nevus management: clinical outcomes, cosmetic satisfaction, and safety-a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Melanocytic nevi are among the most frequently treated lesions in aesthetic dermatology. Various techniques are used for cosmetic or diagnostic purposes. However, comparative evidence regarding treatment efficacy, recurrence risk, cosmetic outcomes, and safety remains inconsistent. Objective: To systematically evaluate and compare clinical clearance, recurrence rates, cosmetic outcomes, and adverse events associated with aesthetic techniques used for the removal of melanocytic nevi. Methods: A systematic search of PubMed, Scopus, Web of Science, ScienceDirect, Wiley, and Google Scholar was conducted for studies published between January 2000 and May 2025. Studies reporting outcomes of surgical or aesthetic interventions for benign melanocytic nevi were included. Data extraction followed PRISMA 2020 guidelines. A random-effects meta-analysis was performed to pool estimates of clinical clearance, recurrence, and cosmetic satisfaction. Subgroup analyses were conducted according to nevus subtype (junctional vs. intradermal) and treatment modality. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool for randomized trials and the Newcastle-Ottawa Scale for observational studies. Results: A total of 46 studies involving 4,201 lesions were included. Surgical excision demonstrated the highest clinical clearance rate (96.4%; 95% CI 92.1-99.2) and the lowest recurrence rate (2.1%). Laser-based treatments produced the most favorable cosmetic outcomes, with Er:YAG laser achieving the highest satisfaction score (8.8/10), followed by CO Conclusion: Surgical excision remains the most reliable method for complete melanocytic nevus removal and histopathologic assessment but may yield less favorable cosmetic outcomes. Laser-based treatments, particularly Er:YAG and CO
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