ArticleDrug design, development and therapy2026
Mivacurium Infusion ED50/ED95 for Maintaining Motor Evoked Potentials During Adolescent Scoliosis Surgery Under TIVA: A Modified Dixon Up-and-Down Sequential Dose-Finding Study.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to determine the median effective dose (ED50) and 95% effective dose (ED95) of mivacurium for maintaining elicitable motor evoked potentials (MEP) under total intravenous anesthesia (TIVA) during adolescent scoliosis surgery, while fulfilling both muscle relaxation and intraoperative neurophysiological monitoring (IONM) requirements. Patients and Methods: 26 adolescents scheduled for primary elective scoliosis surgery with MEP monitoring were enrolled. Anesthesia was maintained with TCI propofol to achieve BIS of 40-60. Infusing mivacurium to maintain train-of-four count 1-3 until surgical exposure was completed. After train-of-four ratio recovered to 75% and MEP waveforms were elicitable, modified Dixon up-and-down sequential method was employed, with an initial mivacurium infusion dose of 10 μg·kg Results: The ED50 was 7.24 μg·kg Conclusion: Under this TIVA/IONM protocol, the ED50 and ED95 for continuous mivacurium infusion that preserves MEP are 7.24 μg·kg
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