ReviewDrug design, development and therapy2026
The Impact of Polymers in Amorphous Solid Dispersion on the Bioavailability of Sulfonylureas and Meglitinides.
Review in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) represents a major and growing global health challenge. Among antidiabetic medications, sulfonylureas and meglitinides remain clinically relevant insulin secretagogues for the management of type 2 DM (T2DM). However, many drugs in these classes belong to Biopharmaceutics Classification System (BCS) Class II, which are characterized by low aqueous solubility and high membrane permeability. These physicochemical constraints result in slow dissolution, variable oral absorption, suboptimal bioavailability and inadequate glycemic control. Converting drugs into their amorphous form can enhance solubility and dissolution; however, amorphous drugs are inherently unstable and prone to recrystallization, limiting their practical use. Amorphous solid dispersion (ASD), which incorporates poorly soluble antidiabetic drugs into a polymeric matrix, offers a promising strategy to overcome these limitations. The polymeric carrier stabilizes the drug in its high-energy amorphous state, improving solubility, dissolution, and ultimately, bioavailability. In ASD systems, drug molecules are dispersed within the polymer matrix at the molecular level, forming extremely fine dispersion domains that may be even smaller than conventional nanoparticle systems, thereby enhancing apparent solubility and dissolution. This review provides a comprehensive overview of ASD applications in antidiabetic therapy, discussing the principles of ASD, commonly used polymeric carriers, fabrication methods, and recent in vitro and in vivo findings. Studies consistently show that ASD formulations of antidiabetic drugs such as glimepiride, repaglinide, gliclazide, gliquidone, and glyburide enhance insulin secretion and contribute to more effective glycemic control, showing the potential of ASD in improving the therapeutic performance of poorly soluble antidiabetic agents. By enhancing solubility, stability, and bioavailability, ASD technology holds significant promise for developing more potent and effective antidiabetic therapies, ultimately supporting better patient care and addressing the global burden of diabetes mellitus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.