ArticleCureus2026
Letrozole-Induced Pneumonitis Complicated by Acute Respiratory Distress Syndrome: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Letrozole is a commonly used aromatase inhibitor in the adjuvant treatment of hormone receptor-positive breast cancer and is generally well tolerated. Pulmonary toxicity is rare and poorly described. We report the case of a 74-year-old woman who developed progressive respiratory symptoms over two months, initially suggestive of infectious pneumonia, but with negative microbiological investigations and no response to multiple antibiotic therapies. Her condition worsened, leading to acute respiratory distress syndrome requiring invasive mechanical ventilation. A drug-induced pneumonitis related to letrozole was suspected. Discontinuation of the drug and initiation of corticosteroid therapy resulted in rapid clinical improvement. This case highlights a rare but potentially severe pulmonary adverse effect that should be considered in patients with unexplained pneumonia.
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Registered trials
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