ReviewCureus2026
Opioid-Induced Nausea and Vomiting in Patients With Cancer: A Narrative Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opioid-induced nausea and vomiting (OINV) represent a frequent and clinically significant complication in patients with cancer. They negatively affect adherence to analgesic therapy, pain control, and overall quality of life. Their pathophysiology is multifactorial and involves activation of the chemoreceptor trigger zone through dopaminergic and serotonergic pathways, impairment of gastrointestinal motility leading to delayed gastric emptying and reduced peristalsis, and vestibular modulation mediated by histaminergic and muscarinic pathways. These mechanisms are further influenced by individual susceptibility and pharmacological factors. Despite their clinical relevance, international guidelines primarily focus on chemotherapy- or radiotherapy-induced emesis, leaving a gap in the specific management of OINV. This narrative review synthesizes the available evidence and proposes a structured diagnostic and therapeutic approach tailored to this condition. A stepwise management model is presented, integrating non-pharmacological strategies and sequential pharmacological treatment according to the predominant pathophysiological mechanism. Explicit criteria for therapeutic failure and referral to specialized care are also included. This approach aims to optimize symptom control, support rational opioid rotation when indicated, and improve quality of life in patients with cancer receiving palliative care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.