ReviewCureus2026
NovaBone Bioactive Glass for Oral Bone Regeneration: Mechanisms, Innovations, and Clinical Outcomes.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration remains a fundamental component of contemporary oral and implant dentistry, particularly in the management of post-extraction defects, periodontal bone loss, and implant site deficiencies. Among available grafting materials, synthetic bioactive substitutes have gained attention due to their ability to combine scaffold function with biologically active surface properties. NovaBone, a calcium phosphosilicate-based bioactive glass, has emerged as a clinically relevant option owing to its capacity for ionic dissolution, surface reactivity, and the promotion of mineralized tissue formation. This review aims to provide a comprehensive synthesis of the mechanistic basis, material characteristics, and clinical performance of NovaBone in oral bone regeneration. The biological activity of NovaBone is primarily driven by the release of silicon (Si), calcium (Ca), and phosphate ions, which contribute to osteogenic signaling, angiogenesis, and the formation of a hydroxycarbonate apatite (HCA) layer that facilitates bonding with host bone. In addition to its physicochemical properties, advancements in formulation, including putty and composite systems, have improved its clinical handling and adaptability. Clinical evidence indicates that NovaBone demonstrates favorable outcomes in periodontal intrabony and furcation defects, with additional applicability in socket preservation, ridge augmentation, sinus elevation, and peri-implant defect reconstruction. However, the available literature shows variability in study design, follow-up duration, and outcome measures, with relatively limited long-term randomized data specific to NovaBone formulations. Overall, NovaBone represents a promising bioactive graft material that integrates scaffold function with biologically driven regeneration. Its clinical utility is best understood within a mechanism-oriented framework that links material behavior to tissue response. Future research should focus on standardized clinical protocols and high-quality comparative trials to further define its role among contemporary regenerative biomaterials in implant dentistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.