ArticleInternational journal of endocrinology2026
Blood Urea Nitrogen/Creatinine Ratio in Cushing's Syndrome: Associations With Disease Status and Postoperative Changes.
Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Blood Urea Nitrogen/Creatinine Ratio in Cushing's Syndrome: Associations With Disease Status and Postoperative Changes.International journal of endocrinology · 2026Article
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Authors and funding
4 authors.
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Abstract
Objective: Although various tests are used for Cushing's syndrome (CS) screening and diagnosis, none exhibit ideal sensitivity or specificity. This study evaluates the association of the blood urea nitrogen (BUN)/creatinine ratio with disease status in CS and subclinical Cushing's syndrome (SCS), and with postoperative changes in patients with CS. Design: A single-center, observational, cross-sectional study conducted at Endocrinology and Metabolic Diseases Clinic of a tertiary training and research hospital in Istanbul, Turkey (2017-2022). Patients: This study included 229 individuals: 151 CS/SCS patients and 78 healthy controls. CS cases were classified as adrenocorticotropic hormone (ACTH)-dependent ( Measurements: BUN/creatinine ratios were compared among CS, SCS, and control groups, as well as between pre- and posttreatment states in CS patients. Correlations between BUN/creatinine ratio and standard CS diagnostic tests were analyzed. Receiver operating characteristic (ROC) analysis was performed to evaluate the discriminatory performance of the BUN/creatinine ratio between CS and control groups. Results: BUN/creatinine ratios were significantly higher in CS, ACTH-independent CS, and SCS groups compared to controls. Cutoff values were > 15.34 for CS, > 13.67 for ACTH-independent CS, and > 19.8 for SCS. The BUN/creatinine ratio correlated positively with basal plasma cortisol, 1 mg dexamethasone suppression test (DST), and midnight serum cortisol in ACTH-dependent CS ( Conclusions: The BUN/creatinine ratio may provide supportive information associated with CS status and postoperative changes in patients with CS, particularly when standard tests are unavailable or inconclusive. Larger multicenter studies are needed to confirm its clinical utility.
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