Evidence map›Paper›PMID 42291802›Full record

ArticleFrontiers in synaptic neuroscience2026

Automated ROI detection allows rapid quantification of synaptic activity across tens of thousands of synapses in cell culture.

John Carl Begley, Harald Prüss, Paul Turko, Camin Dean

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

John Carl BegleyInstitute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Harald PrüssGerman Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.
Paul TurkoShared Primary Neuron Facility (SPNF), Institute for Integrative Neuroanatomy, Charité - Universitätsmedizin, Berlin, Germany.
Camin DeanGerman Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synapses are the basic unit of information transfer between neurons. Their dysfunction is a common trigger of cognitive diseases and disorders. However, high-throughput analysis methods to assess synaptic function and dysfunction are lacking. Calcium imaging in cultured neurons in the absence of Mg

Indexed as

automated ROI detectioncalcium imagingNMDAR auto-antibodiespost-synaptic functionpresynaptic function

Identifiers

PMID42291802
PMCPMC13254171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.