ArticleJournal of oral microbiology2026
Antibacterial and anti-biofilm effects of postbiotic mediator derived from
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dental caries, commonly known as tooth decay, is a progressive breakdown of tooth tissues caused by the biofilm-producing bacteria, Aim: This study aimed to evaluate the antibacterial and anti-biofilm effects of the neutralized postbiotic mediator (nPM) derived from Methods: KMC12 nPM was prepared through centrifugation, filtration and lyophilization. Its antibacterial and anti-biofilm effects were investigated through MIC/MBC assays, membrane permeability tests, biofilm formation quantification, EPS production measurement, RT-qPCR analysis of biofilm-related genes, and cytotoxicity assays using Caco-2 cells. Results: KMC12 nPM exhibited antibacterial activity with MIC and MBC values of 128 and 256 mg/mL, respectively, and caused approximately 87% membrane damage at 512 mg/mL. Biofilm formation was inhibited by 36% at 256 mg/mL and 83% at 512 mg/mL. Furthermore, KMC12 nPM significantly downregulated Conclusion: These results suggest KMC12 nPM as a promising, novel therapeutic agent for inhibiting
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