ArticleInternational journal of genomics2026
Investigation of Pharmacogenomic Variants in the CYP (P450) Family in Native American Populations of the Brazilian Amazon.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Investigation of Pharmacogenomic Variants in the CYP (P450) Family in Native American Populations of the Brazilian Amazon.International journal of genomics · 2026Article
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Authors and funding
13 authors.
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Abstract
The cytochrome P450 (CYP) enzyme superfamily is essential for xenobiotic metabolism, detoxification pathways, and the regulation of cellular homeostasis. Genetic variability in CYP genes, together with environmental factors, contributes substantially to interindividual and interethnic differences in drug metabolism and therapeutic response. However, Indigenous populations remain largely underrepresented in pharmacogenomic and population genomics studies, limiting the generalizability of current knowledge. This study is aimed at characterizing genetic variation within CYP genes in Native American populations from the Brazilian Amazon and comparing the observed patterns with those of the five continental populations represented in the 1000 Genomes Project. Whole-exome sequencing data were generated for 64 Indigenous individuals belonging to 12 distinct Amazonian ethnic groups. Variants were identified and annotated across CYP family genes, and their predicted functional impacts were assessed. A total of 506 genetic variants were detected across 63
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