ArticleFrontiers in cardiovascular medicine2026
Differential biomarker responses of hemolysis, inflammation, and myocardial injury after pulsed-field pulmonary vein isolation: balloon-in-basket vs. circular catheter systems.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pulsed-field ablation (PFA) is a non-thermal energy source for pulmonary vein isolation (PVI). Data comparing the biological impact of different PFA technologies remain limited. This study assessed changes in biomarkers of hemolysis, inflammation, and biochemical myocardial injury using two PFA systems: a balloon-in-basket (BiB) and a circular catheter (PS). Methods: This prospective, single-center, non-randomized study enrolled consecutive patients undergoing first-time PVI. leukocytes, C-reactive protein (CRP), platelets, lactate dehydrogenase (LDH), haptoglobin, total bilirubin, troponin T, creatine kinase (CK), myoglobin, creatinine, and estimated glomerular filtration rate (eGFR) were before and 16-18 h after ablation. Results: Forty patients were included (BiB Conclusion: Despite comparable overall biomarker responses, a numerically greater, non-significant haptoglobin decline and an isolated, likely multifactorial transient AKI in the PS group may suggest differences in biomarker responses, warranting further investigation in larger studies. However, the clinical relevance of these findings remains uncertain.
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