ArticleFrontiers in cardiovascular medicine2026
The association between time-weighted cumulative life's essential 8 and aortic valve calcification.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To examine the association between the time-weighted cumulative Life's Essential 8 (TWC-LE8) score and aortic valve calcification (AVC). Methods: This analysis included 15,321 adults (mean age, 63.79 years; 76.44% men) from the Kailuan cohort who completed four health examinations between 2006 and 2012 and subsequently underwent standardized echocardiography. The TWC-LE8 score (range, 0-100) was used to classify cardiovascular health (CVH) as low (<50), moderate (50-79), or high (≥80). Multivariable logistic regression was used to estimate odds ratios (ORs) for AVC across CVH categories, and restricted cubic spline models were applied to assess the dose-response relationship. Results: A total of 2,894 AVC cases were identified. Compared with low CVH, moderate CVH was associated with lower odds of AVC (OR = 0.53, 95% CI: 0.47-0.61), and high CVH was associated with even lower odds of AVC (OR = 0.25, 95% CI: 0.15-0.40). A linear inverse association between TWC-LE8 score and AVC was observed (P for trend < 0.001). Age-stratified analyses showed significant heterogeneity. Among participants aged ≥55 years, high CVH was associated with 74% lower odds of AVC (OR = 0.26, 95% CI: 0.15-0.45), whereas no significant association was observed among those aged <55 years. Conclusion: Higher cumulative LE8 scores were strongly associated with lower odds of AVC, particularly among older adults. These findings support an inverse association between long-term cardiovascular health and AVC.
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