ArticleFrontiers in cardiovascular medicine2026
Remote ischemic preconditioning in elderly patients with acute myocardial infarction and transient ischemic attack: a retrospective cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elderly patients who experience acute myocardial infarction (AMI) in temporal proximity to transient ischemic attack (TIA) carry a high inflammatory burden and a disproportionate risk of recurrent cardio-cerebrovascular events. Remote ischemic preconditioning (RIPC) has been hypothesized to provide systemic protection through neurohumoral and immunomodulatory pathways, but clinical data in this dual-organ ischemia phenotype are limited. Methods: We performed a single-center retrospective cohort study (2018-2023) of patients aged ≥60 years with AMI complicated by neurologist-adjudicated TIA. Patients received guideline-directed care with or without adjunctive RIPC per treating physician judgment. The RIPC protocol consisted of four cycles of 5-min brachial cuff inflation (200 mm Hg or ≥20 mm Hg above systolic pressure) and 5-min deflation, twice daily for 14 days, initiated within 24 h when feasible. The primary endpoint was 12-month major adverse cardiac and cerebrovascular events (MACCE). Time-to-event analyses included Kaplan-Meier estimates and Cox models; the multivariable model adjusted for age, sex, diabetes, left-ventricular ejection fraction (LVEF), log_e interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and ACE-inhibitor therapy. Results: Of 382 patients screened, 103 were analyzed (RIPC, 48; control, 55). Baseline characteristics were well balanced (all Conclusions: In an elderly cohort with AMI complicated by TIA, adjunctive RIPC was associated with a lower 12-month risk of MACCE after adjustment for clinical and inflammatory covariates, with consistent directional benefits across cardiac and cerebrovascular components and a favorable safety/adherence profile. Baseline IL-6 and hs-CRP were independent determinants of risk, and was consistent with an inflammation-linked pathobiology in which conditioning-based strategies warrant prospective evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.