ArticleFrontiers in cardiovascular medicine2026
E/e' ratio combined with left ventricular mass index predicts HFpEF rehospitalization risk in stage 3-4 chronic kidney disease patients: a retrospective cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Patients with heart failure with preserved ejection fraction (HFpEF) and coexisting chronic kidney disease (CKD) have poor outcomes. This study assessed whether a combined echocardiographic indicator could improve risk stratification for this high-risk group. Methods: In a retrospective study of 254 adults with HFpEF and stage 3-4 CKD, we evaluated an indicator combining elevated E/e' ratio (≥15) and left ventricular hypertrophy (LVH). The primary outcome was rehospitalization for HFpEF. Statistical analyses included Cox regression, C-index, and decision curve analysis. Results: Over a 2.1-year median follow-up, 26.8% of patients were rehospitalized. The combined indicator was a strong, independent predictor of this outcome. It demonstrated superior discrimination (C-index 0.74) compared to either E/e' (0.67) or LVH (0.65) alone, showing clinical utility across a range of risk thresholds. Conclusion: A combined echocardiographic indicator integrating E/e' and LVMI improves risk stratification in patients with HFpEF and advanced CKD.
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