ArticleEuropean heart journal open2026
Proximal tubule reabsorptive dysfunction and risk of cardiovascular death among community-living adults: the HUNT-3 cohort.
Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: Proximal tubule dysfunction in the kidney is associated with cardiovascular disease (CVD) in populations with prevalent chronic kidney disease (CKD). We sought to evaluate the nature of this association in the general population. Methods and results: We conducted a case-cohort study within the North Trøndelag Health Study (HUNT-3). We randomly sampled 1246 participants and all cases of cardiovascular death. Alpha-1 microglobulin (A1M) and beta-2 microglobulin (B2M) were measured in urine to assess proximal tubule reabsorptive dysfunction. Cardiovascular death was assessed using the Norwegian Cause of Death registry. We estimated the association of each biomarker with cardiovascular death after adjustment for baseline characteristics, including estimated glomerular filtration rate (eGFR) and albuminuria. Mean participant age was 51 years, 55% were female. Median urine albumin-to-creatinine ratio was 1.3 [interquartile range (IQR) 1.0-1.8] mg/mmol and mean eGFR was 98 (SD 17) mL/min/1.73 m Conclusion: In a population-based cohort of adults, proximal tubule reabsorptive dysfunction, as indicated by elevated levels of urinary A1M and B2M, was associated with higher risk of cardiovascular death independent of eGFR and albuminuria.
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