Evidence map›Paper›PMID 42291441›Full record

SynthesisPeerJ2026

Comparison of XEN gel stent for management of open-angle glaucoma: a systematic review and meta-analysis.

Xiangjun Fu, Guoliang Li, Juan He, Hongyi Luo, Ruijue Peng, Yilian Cheng, Jie Peng, Shiyan Chen, Chao Qu

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiangjun Fu *School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Guoliang Li *Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Juan HeSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Hongyi LuoChengdu University of Traditional Chinese Medicine, Chengdu, China.
Ruijue PengSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yilian ChengSichuan Provincial People's Hospital, Chengdu, China.
Jie PengSichuan Provincial People's Hospital, Chengdu, China.
Shiyan ChenSichuan Provincial People's Hospital, Chengdu, China.
Chao QuSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The comparative efficacy of XEN gel stent implantation, either as a standalone procedure (XEN-only) or combined with phacoemulsification (Phaco-XEN), for the treatment of open-angle glaucoma (OAG) warrants further investigation. This systematic review and meta-analysis evaluated the efficacy of XEN-only and Phaco-XEN procedures compared to trabeculectomy (TB). Methods: Five major electronic databases, including PubMed, ScienceDirect, and the Cochrane Library, were systematically searched from inception to September 1, 2025. We compared clinical outcomes among XEN-only, Phaco-XEN, and TB groups. Stratification analyses examined outcomes based on follow-up duration and geographic location. Efficacy endpoints included intraocular pressure (IOP), number of anti-glaucoma medications (NOAM), and bleb needling rates. Sensitivity analyses were performed to assess potential biases. Results: A total of 56 eligible studies were included. (1) Both XEN-only and Phaco-XEN procedures achieved significant IOP reductions from baseline ( Conclusion: Both XEN-only and Phaco-XEN surgeries provide effective IOP reduction. There was no statistically significant difference in postoperative NOAM reduction between XEN-only and Phaco-XEN surgeries (

Indexed as

Glaucoma, Open-AnglePhacoemulsificationStentsHumansIntraocular PressureTrabeculectomyTreatment OutcomeGlaucoma surgeryMinimally invasive glaucoma surgeryOpen-angle glaucomaXEN gel stent

Identifiers

PMID42291441
PMCPMC13262562

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.