ArticleIranian journal of basic medical sciences2026
Transforming PRP into a shelf-stable therapy: Lyophilization preserves angiogenic and regenerative properties.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Platelet-rich plasma (PRP) is widely used in regenerative medicine due to its high concentration of bioactive growth factors; however, its short shelf life limits its clinical applicability. Lyophilization has been proposed to extend PRP stability, but its impact on biological efficacy remains unclear. This study evaluated whether lyophilization alters the biochemical composition and regenerative function of PRP derived from expired platelet units unsuitable for transfusion. Materials and Methods: Pooled isogroup PRP was processed as either liquid PRP or lyophilized PRP. Growth factors (FGF-1, PDGF, VEGF) and endotoxin levels were quantified. Biological activity was assessed in human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs) using MTT assays, Results: Lyophilization resulted in moderate reductions in FGF-1, PDGF, and VEGF relative to Liquid-PRP ( Conclusion: Despite a moderate reduction in growth factors, lyophilized PRP retained regenerative efficacy, supporting lyophilization as a viable strategy for the stable, sustainable reuse of PRP.
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