ArticleTranslational lung cancer research2026
Diagnostic accuracy and safety of 1.1-mm cryoprobe biopsy for peripheral pulmonary lesions with or without oversheath.
Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cryobiopsy using a 1.1-mm probe enables the acquisition of larger and better-preserved tissue specimens for peripheral pulmonary lesions (PPLs). However, the effects of oversheathed cryobiopsy on diagnostic performance and procedural safety remain uncertain. This study aimed to evaluate whether the use of an oversheath influences diagnostic performance and procedural safety during bronchoscopic biopsy of PPLs using a 1.1-mm cryoprobe. Methods: This single-center retrospective study included 85 patients who underwent bronchoscopic biopsy for PPLs ≤30 mm in diameter using a 1.1-mm cryoprobe between March 2022 and August 2023. Patients were categorized into two groups according to oversheath use: procedures performed with an oversheath (n=39) and those performed without an oversheath (n=46). Diagnostic success rates, and procedure-related complications were evaluated, with particular focus on bleeding events. Results: Cryobiopsy using a 1.1-mm probe achieved a significantly higher diagnostic yield compared with that via forceps biopsy (70.6% Conclusions: Cryobiopsy using a 1.1-mm probe provides a superior diagnostic yield compared with that via forceps biopsy for PPLs. The use of an oversheath during cryobiopsy reduces bleeding complications and may further improve diagnostic performance, particularly in smaller lesions.
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