ArticleFrontiers in cellular and infection microbiology2026
Microbial modulation of proteoglycan and glycosaminoglycan biosynthesis in a three-dimensional corneal epithelium model.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Bacterial-Derived Signals Selectively Remodel Glycosaminoglycan Biosynthetic Pathways in Reconstructed Human Corneal Epithelium.International journal of molecular sciences · 2026Article
- Bacterial extracellular vesicles and direct microbial contact drive species-specific corneal epithelial reprogramming.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recently, a three-dimensional Methods: In this study, we analyzed the transcriptional profiles of genes involved in PG and GAG biosynthesis in the QobuR model following controlled co-culture with individual bacterial species and with a mixed microbial consortium designed to represent the ocular surface microbiota. Expression changes were assessed by qRT-PCR and complemented by immunohistochemical analysis. Results: Distinct bacterial species induced specific patterns of gene expression, predominantly affecting enzymes involved in late-stage sulfation of heparan sulfate and chondroitin sulfate chains. Exposure to the microbial consortium resulted in broader and more complex transcriptional modulation, incorporating most changes observed in individual conditions while introducing additional alterations. Notably, the transcriptional profile of microbiota-exposed QobuR showed increased similarity to donor-derived corneal epithelium. These observations were supported by immunohistochemical analyses. Conclusions: These findings demonstrate that corneal epithelial cells exhibit dynamic transcriptional responses to microbial exposure under controlled
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