Evidence map›Paper›PMID 42291326›Full record

ArticleFrontiers in cellular and infection microbiology2026

A single amino acid substitution determines susceptibility of

Kerisa Hall, Ishrya Sharma, Shasika Jayarathne, Hiba Osmani, Drishya Sudarsanan, Shannon Moonah

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kerisa Hall *Department of Medicine, University of Florida, Gainesville, FL, United States.
Ishrya Sharma *Department of Medicine, University of Florida, Gainesville, FL, United States.
Shasika JayarathneDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Hiba OsmaniCollege of Medicine, University of Vermont, Burlington, VT, United States.
Drishya SudarsananDepartment of Medicine, University of Florida, Gainesville, FL, United States.
Shannon MoonahDepartment of Medicine, University of Florida, Gainesville, FL, United States.

Funding

CD74 and Wound HealingR01DK131313 · NIDDK · UNIVERSITY OF VIRGINIA · PI Shannon Moonah · 2022 to 2026
$1.8M
NIDDK NIH HHS R01 DK131313
6 · The paper itself

Abstract

Monoclonal antibodies have become an integral component of modern therapeutics, however, their efficacy can be diminished by variation in target proteins, emphasizing the need to define these changes to guide the development of effective therapies. In this brief report, we uncover the molecular mechanism underlying a key limitation of bezlotoxumab, a monoclonal antibody targeting

Indexed as

Amino Acid SubstitutionAntibodies, BacterialAntibodies, MonoclonalAntibodies, NeutralizingBacterial ProteinsBacterial ToxinsClostridioides difficileBroadly Neutralizing AntibodiesCell LineEpithelial CellsHumansAntibodies, BacterialAntibodies, MonoclonalAntibodies, NeutralizingBacterial ProteinsBacterial ToxinsbezlotoxumabBroadly Neutralizing AntibodiestoxB protein, Clostridium difficileamino acid substitutionantibodyC. difficilecell deaththerapeuticsvariants

Identifiers

PMID42291326
PMCPMC13253237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.