SynthesisFrontiers in cellular and infection microbiology2026
Profiling of human lung and gut microbiomes in different conditions of chronic obstructive pulmonary disease using ontology-based evidence synthesis and reasoning.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Gut microbiota dysbiosis and the gut-lung axis in COPD: mechanisms, clinical relevance, and microbiota-targeted interventions.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic Obstructive Pulmonary Disease (COPD) remains one of the leading global causes of morbidity and mortality, with increasing evidence highlighting microbial dysbiosis as a key factor in disease progression and exacerbation. To resolve the inherent heterogeneity in COPD microbiome research, we developed a standardized pipeline termed as Ontology-based Evidence Synthesis and Reasoning (O-ESR), utilizing the Ontology of Host-Microbiome Interactions (OHMI) framework. Our analysis included over 30 studies and identified more than 100 significantly altered bacterial taxa in the human airway and gut microbiomes of human COPD patients across three clinical conditions: COPD versus healthy controls, exacerbation versus stable states, and severe versus moderate diseases. Profiling across taxonomic levels revealed a marked airway expansion of pathogenic genera, including
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Registered trials
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