ArticleFrontiers in cellular and infection microbiology2026
Drug repurposing: a dual-mechanism antibiotic combats MRSA and its high resistant phenotypes.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Methicillin-resistant Methods: By drug repurposing, this study determines the antibacterial activity of the anti-amoebic small molecule tiliquinol against MRSA and its highly drug-resistant biofilms and evaluates its potential to induce MRSA resistance. The antibacterial mechanism of tiliquinol is examined utilizing transcriptomics, fluorescent probes, and quantitative reverse-transcription polymerase chain reaction. In addition, we evaluate Results: The research find that tiliquinol exhibits notable antibacterial activity against MRSA and its highly resistant biofilms avoiding resistance occurrence. Mechanism study reveals that the proton motive force and peptidoglycan are potential therapeutic targets by tiliquinol. Further, in various mouse infection models, favorable Conclusion: Tiliquinol is recognized as a novel therapeutic strategy against refractory MRSA-related infections, particularly those associated with osteomyelitis and implant-related complications.
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