ArticleFrontiers in cellular and infection microbiology2026
Single and combined use of the platelet-lymphocyte ratio and neutrophil-lymphocyte ratio in hemorrhagic fever with renal syndrome.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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- Erratum issued
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8 authors.
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Abstract
Objective: This study aims to evaluate the diagnostic performance of the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) in hemorrhagic fever with renal syndrome (HFRS). Methods: This retrospective study included 215 patients with HFRS (HFRS group) and 256 healthy controls (HC group). Peripheral blood samples were collected to measure platelet counts (PLT), and PLR and NLR were subsequently calculated. Multivariate logistic regression was used to adjust for the confounding effects of age and gender. Receiver operating characteristic (ROC) curves, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) assessed their predictive performance. Results: For HFRS diagnosis, the AUC of PLR (0.8141; 95% CI 0.7682-0.8600) was higher than that of NLR (0.6412; 95% CI 0.5882-0.6942). PLT count achieved the highest AUC (0.8729; 95% CI 0.8356-0.9102), specificity (94.92%) and sensitivity (76.74%). The combined PLT, PLR, and NLR achieved a significantly greater AUC (0.9029, NRI 0.234, IDI 0.002, all P < 0.05) than individual indicators. After adjusting for age and gender, PLT, PLR, and NLR remained significant independent predictors of HFRS. NLR showed a significant age - dependent increase, with older patients exhibiting the highest values. Conclusion: PLT, PLR, and NLR especially their combination, may be valuable and accessible biomarkers for the adjunctive diagnosis of HFRS.
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