ArticleFrontiers in cellular and infection microbiology2026
Specific gut microbiota alterations and metabolic deficits in Parkinson's disease: a controlled comparison with functional constipation.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To isolate Parkinson's disease (PD)-specific gut dysbiosis from motility-related changes, this study compared the fecal microbiota of PD patients with constipation (PDC, n=20) against a functional constipation (FC, n=15) control group. Methods: High-throughput 16S rRNA gene sequencing and functional prediction were performed on fecal samples. Diversity metrics and taxonomic compositions were analyzed to identify PD-specific signatures. Results: The PDC group exhibited significantly higher microbial richness than the FC group (P = 0.01). Despite structural similarities driven by the shared constipation phenotype (ANOSIM R = 0.084), PDC was distinguished by specific compositional shifts, including the enrichment of Conclusion: By controlling for colonic transit time, this study identified specific microbial alterations and metabolic deficits in PD independent of constipation. These findings support a "gut-first" etiology linked to specific pathobionts and barrier compromise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.