Observational studyFrontiers in cellular and infection microbiology2026
Endothelial, cytokine, and Th1/cellular host biomarkers discriminate complicated osteoarticular tuberculosis: a prospective single-center cohort study with ROC analysis.
Observational study in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarticular tuberculosis (OATB) accounts for 10-15% of extrapulmonary TB cases and causes progressive bone destruction, neurological compromise, and persistent disability. No validated host-based framework currently identifies patients at high risk of complicated disease course at baseline, and the integrated role of cellular, cytokine, endothelial, and fibrinolytic axes in OATB has not been systematically characterized. Methods: We conducted a prospective single-center observational study at Bukhara Regional Center of Phthisiopulmonology, Uzbekistan. Of 223 consecutive eligible adults with confirmed OATB, 115 met immunological-cohort criteria, with peripheral blood drawn before anti-tuberculosis chemotherapy. Results: Nine markers achieved high prognostic discrimination: sICAM-1 (0.89), IL-6 (0.88), sVCAM-1 (0.87), CD4/CD8 (0.86), IP-10 (0.85), TNF-α (0.84), CD95 Conclusions: Nine individually high-performing baseline markers discriminate complicated from uncomplicated OATB with clinically useful accuracy, with endothelial-fibrinolytic markers contributing the highest AUC values. External validation in multi-center cohorts is the essential next step toward routine OATB risk stratification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.