ReviewFrontiers in oral health2026
Antimicrobial effectiveness of intracanal medicaments against
Review in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Persistent endodontic infections are frequently associated with Objectives: This systematic review aimed to evaluate the antimicrobial effectiveness of intracanal medicaments against Methods: A systematic review was conducted following PRISMA 2020 guidelines. Searches were performed in PubMed/MEDLINE, Scopus, and Embase. Eligible studies included Results: Twelve studies were included. Antibiotic-based medicaments, particularly triple antibiotic paste, generally showed comparatively stronger antimicrobial performance, especially in studies assessing bacterial reduction and biofilm-related outcomes. Calcium hydroxide showed variable and generally lower efficacy, especially in deeper dentinal regions, though combination therapies improved performance. Novel agents, including nanoparticle-based systems and bioactive compounds, showed promising but heterogeneous results. Quantitative pooling was limited to two studies and revealed extreme heterogeneity with imprecise estimates. Overall certainty of evidence ranged from low to moderate. Conclusions: Intracanal medicaments exhibit consistent antimicrobial activity against Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/recorddashboard, identifier CRD420261345958.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.