Lineage tracing of soma-to-primordial germ cell-like conversion in human tumor cell line.

Jing Li, Fengyu Zhang, Ji Xiong, Aiping Liu, Peipei Liu, Zhan Ma, Hui-Kuan Lin, Chunfang Liu

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing LiDepartment of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Fengyu ZhangDepartment of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Ji XiongDepartment of Pathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Aiping LiuDepartment of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Peipei LiuDepartment of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Zhan MaDepartment of Laboratory Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200040, China.

Hui-Kuan LinDepartment of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

Chunfang LiuDepartment of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying the origin of tumor-initiating ability is critical for targeted therapies. While early primordial germ cells (PGCs) inherently possess this ability, our previous study indicated that soma-to-PGC-like conversion (SPLC) facilitates its acquisition in mouse breast tumor cells. This study reports evidence of SPLC activation in the human hepatic tumor cell line HL7721, where tumor cells spontaneously exhibit sequential developmental stages, progressing from somatic tumor cells through intermediate stages to PGC-like and late germ cell-like stages. Knocking out PGC specification inducers (

Indexed as

Biological sciences

Identifiers

PMID42291258

DOI10.1016/j.isci.2026.116214

PMCPMC13254981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.