Evidence map›Paper›PMID 42291230›Full record

ArticleiScience2026

TET3 promotes preeclampsia by regulating PDK4-mediated glucose metabolism reprogramming in trophoblasts.

Xiaokang Deng, Yi Liu, Meilikang Li, Weichun Tang, Lingling Jiang, Juveria Rahman, Matthew Sagnelli, Hongtao Hu, Lizhou Sun, Qing Zuo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaokang DengDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
Yi LiuDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
Meilikang LiDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
Weichun TangDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Yale University School of Medicine, NewHaven, CT 06510, USA.
Lingling JiangDepartment of Obstetrics, Gynecology, & Reproductive Sciences, Yale University School of Medicine, NewHaven, CT 06510, USA.
Juveria RahmanDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
Matthew SagnelliDepartment of Obstetrics, Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, Nantong, Jiangsu Province 226000, China.
Hongtao HuDepartment of Radiology, Lenox Hill Hospital, Northwell Health, 100 East 77th Street, New York, NY 10075, USA.
Lizhou SunDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
Qing ZuoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Dan WuDepartment of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 Tianfeixiang, Mochou Road, Qinhuai District, Nanjing 210004, China.
Yetao XuDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extra villous trophoblasts (EVTs) dysfunction impairing spiral artery remodeling (SAR) is a key preeclampsia (PE) factor. ScRNA-seq and bioinformatics analyses of preeclamptic placentas revealed the upregulation of TET3, a newly recognized regulator of epigenetic reprogramming. Untargeted metabolomics further associated TET3 with the trophoblast glucose metabolism.

Indexed as

epigeneticsmetabolomicspregnancy

Identifiers

PMID42291230
PMCPMC13264119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.