Evidence map›Paper›PMID 42291216›Full record

ArticleiScience2026

Circulating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer.

Amanda B Figueiredo, Guilherme F B Evangelista, Stephanie M I Ferreira, Larissa M Kuil, Gabriela Barbeta, Lukas C Iohan, Andrea T Faccio, Karina H M Cardozo, Valdemir M Carvalho, Clara M Cavalcanti and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Amanda B FigueiredoTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Guilherme F B EvangelistaTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Stephanie M I FerreiraTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Larissa M KuilTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Gabriela BarbetaTranslational Immuno-oncology Laboratory, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Lukas C IohanTranslational Immuno-oncology Laboratory, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Andrea T FaccioGrupo Fleury, São Paulo, SP, Brazil.
Karina H M CardozoGrupo Fleury, São Paulo, SP, Brazil.
Valdemir M CarvalhoGrupo Fleury, São Paulo, SP, Brazil.
Clara M CavalcantiTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Robert BalderasBD Biosciences, San Jose, CA, USA.
Rodrigo P LopesBD Biosciences, San Jose, CA, USA.
James TurnerSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Thaiany G Souza-SilvaDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Juan C S SilvaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Jonathan P AvilaComputational Systems Biology Laboratory, Education and Research Center, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Helder T I NakayaComputational Systems Biology Laboratory, Education and Research Center, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Nayane A L GaldinoTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Ananda D LopesTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Kátia L P MoraisTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Iasmim P SantosTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Helano C FreitasLung and Thorax Reference Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Jefferson L GrossLung and Thorax Reference Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Clóvis A L PintoPathologic Anatomy Department, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Rubens ChojniakDiagnostic Imaging Department, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Walderez O DutraDepartment of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Vladmir C Cordeiro-de-LimaLung and Thorax Reference Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Kenneth J GollobTranslational Immuno-oncology Group, International Research Center, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy efficacy varies among patients with advanced non-small cell lung cancer (NSCLC). Here, we profiled baseline systemic immunity in patients with stage IV NSCLC treated with anti-PD-1 plus chemotherapy to identify immune mechanisms and circulating biomarkers associated with response. We prospectively enrolled 33 treatment-naive patients, including 22 responders and 11 non-responders at week 9, and 17 responders and 16 non-responders at 6 months. Responders showed increased frequencies of circulating T cells expressing CD69, TCF-1, and CXCR3. In contrast, non-responders exhibited higher frequencies of CTLA-4-, CD161-, and IL-10-expressing CD4

Indexed as

immune systemoncologytherapeutics

Identifiers

PMID42291216
PMCPMC13264123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.