Evidence map›Paper›PMID 42291204›Full record

ArticleiScience2026

Pathological extracellular matrix changes in decellularized normal appearing gray matter and subpial multiple sclerosis lesions.

Jody M de Jong, Justina C Wolters, Marion H C Wijering, Joop de Vries, Susanne M Kooistra, Bart J L Eggen, Wia Baron

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jody M de JongDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Justina C WoltersLaboratory of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marion H C WijeringDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Joop de VriesBiomaterials & Biomedical Technology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Susanne M KooistraDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bart J L EggenDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wia BaronDepartment of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic CNS disease characterized by demyelinated lesions. Gray matter lesions (GMLs) are associated with neurodegeneration and clinical disability, and normal appearing gray matter (NAGM) also shows neuropathology. The extracellular matrix (ECM) supports neuronal health, with perineuronal nets (PNNs) regulating synaptic stability. Microglia remodel the ECM by secreting matrix metalloproteinases, while ECM composition affects microglia behavior. We examined ECM composition in decellularized human control gray matter, NAGM and GML slices and investigated its effects on microglia. Label-free quantitative mass spectrometry of decellularized control gray matter and NAGM revealed differential abundances in PNN ECM components and condition-specific synaptic and basement membrane ECM components. ECM composition was similar between decellularized GMLs and perilesional gray matter. Microglia introduced to decellularized NAGM and GML slices lost IBA1 expression in half the cells, while some remaining IBA1+ microglia acquired proinflammatory marker inducible nitric oxide synthase (iNOS). These findings suggest ECM alterations in NAGM influencing microglial characteristics potentially contributing to MS pathology.

Indexed as

Clinical neuroscienceHealth sciencesMedical specialtyMedicineNeurology

Identifiers

PMID42291204
PMCPMC13264259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.