Evidence map›Paper›PMID 42291182›Full record

ArticleiScience2026

A mechanism of target mRNA selection and activity regulation in meiosis-related RBM46-MEIOC-YTHDC2 complex.

Ruixin Liang, Qizi Chen, Jiawei Li, Han Liu, Yanqiu Ma, Shenglin Han, Yunxin Li, Jingyu Gao, Lan Ye, Jian Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruixin LiangDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.
Qizi ChenDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.
Jiawei LiDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.
Han LiuDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.
Yanqiu MaDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.
Shenglin HanState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.
Yunxin LiState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.
Jingyu GaoDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.
Lan YeSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Jian ZhouDepartment of Pediatric Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MEIOC and its two partners, RBM46 and YTHDC2, function as posttranscriptional regulators to promote mitotic-to-meiotic transition in mammalian germ cells. However, the molecular mechanism underlying target mRNA selection and degradation by MEIOC complex is largely unknown. Here, we demonstrate that exogenously expressed RBM46/MEIOC/YTHDC2 binds to

Indexed as

Molecular mechanism of gene regulationMolecular network

Identifiers

PMID42291182
PMCPMC13254979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.