Evidence map›Paper›PMID 42291173›Full record

ArticleTranslational gastroenterology and hepatology2026

CT-defined sarcopenia as a predictive factor in patients undergoing portal vein embolization: a systematic review and meta-analysis.

Hans-Jonas Meyer, Silke Zimmermann, Alexey Surov

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Article in Translational gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Hans-Jonas Meyer *Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Silke Zimmermann *Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital, Leipzig, Germany.
Alexey Surov *Institute for Radiology, Neuroradiology and Nuclear Medicine, Johannes Wesling University, Ruhr University Bochum, Minden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcopenia can be assessed by cross-sectional imaging and is a prognostic imaging marker in several diseases and tumor entities. First reports demonstrated a significant impact of the presence of sarcopenia on the outcome of portal vein embolization (PVE). The present analysis sought to investigate the effect of computed tomography (CT)-defined sarcopenia in patients undergoing PVE based on a meta-analysis. Methods: MEDLINE library was screened for papers analyzing the association between CT-defined sarcopenia/low skeletal muscle mass and the treatment outcome of PVE up to February 2026. The primary endpoints of the systematic review were the increase or the volume or the growth rate per week of mean future liver remnant (FLR) in % between the groups stratified by sarcopenia. The random-effect model was used for the statistical analysis. Results: The meta-analysis comprised a total of seven studies with 599 patients with different malignant tumors undergoing PVE. For the effect of the future liver remnant volume (FLRV), the pooled mean difference (MD) between the sarcopenic and non-sarcopenic group was 2.70% [95% confidence interval (CI): 0.31-5.09], P=0.03, favoring non-sarcopenia. For the effect of the FLRV increase in %, the pooled MD between the sarcopenic and non-sarcopenic group was 10.87% (95% CI: 3.45-18.30), P=0.004. The pooled correlation coefficient between the skeletal muscle index (SMI) and the liver growth rate after PVE was 0.40 (95% CI: 0.17-0.63), P<0.001. Conclusions: No statistically effects were identified for the impact on resection rate, 90-day mortality and postoperative liver failure. CT-defined sarcopenia has a statistically but not clinically impact on the FLR in patients undergoing PVE.

Indexed as

Meta-analysisportal vein embolization (PVE)sarcopeniasystematic review

Identifiers

PMID42291173
PMCPMC13263961

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