Evidence map›Paper›PMID 42291148›Full record

ArticleFrontiers in audiology and otology2025

Polarity sensitivity to symmetric, biphasic monopolar pulses is not a reliable indicator of peripheral axonal degeneration in human cochlear implant users.

Shuman He, Jacob J Oleson, Zi Gao

Abstract read
In one paragraph

Article in Frontiers in audiology and otology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuman HeDepartment of Otolaryngology - Head and Neck Surgery, The Ohio State University, 915 Olentangy River Road, Columbus, OH 43212.ORCID 0000-0002-6409-7388
Jacob J OlesonDepartment of Biostatistics, The University of Iowa, Iowa City, IA 52242.ORCID 0000-0001-6343-3274
Zi GaoDepartment of Otolaryngology - Head and Neck Surgery, The Ohio State University, 915 Olentangy River Road, Columbus, OH 43212.ORCID 0009-0000-2508-4448

Funding

NEURAL ENCODING AND AUDITORY PERCEPTION IN COCHLEAR IMPLANT USERSR01DC016038 · NIDCD · OHIO STATE UNIVERSITY · PI HE, SHUMAN · 2017 to 2021
$2.3M
Neural Encoding and Auditory Processing of Electrical Stimulation in Pediatric Cochlear Implant UsersR01DC017846 · NIDCD · OHIO STATE UNIVERSITY · PI HE, SHUMAN · 2019 to 2024
$2.0M
AUDITORY NEURAL FUNCTION IN IMPLANTED PATIENTS WITH USHER SYNDROMER21DC019458 · NIDCD · OHIO STATE UNIVERSITY · PI HE, SHUMAN · 2021 to 2022
$433k
NIDCD NIH HHS R01 DC016038NIDCD NIH HHS R01 DC017846NIDCD NIH HHS R21 DC019458
6 · The paper itself

Abstract

This study aimed to determine whether the effect of changing stimulus polarity on the electrically evoked compound action potential (eCAP) threshold - referred to as the polarity effect - could be used to assess the degeneration of the peripheral axon of the cochlear nerve (CN) in human cochlear implant (CI) users. The polarity effect, measured using symmetric, biphasic pulses delivered in a monopolar-coupled stimulation mode, was systematically compared among four cochlear-implanted patient populations with differing CN statuses: children with cochlear nerve deficiency, children with biallelic Gap Junction Beta-2 gene mutations, children with idiopathic sensorineural hearing loss, and postlingually deafened adults with various etiologies. All patients used a Cochlear

Indexed as

cochlear implantcochlear nerveneural healthperipheral axon degenerationpolarity effect

Identifiers

PMID42291148
PMCPMC13256339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.