Evidence map›Paper›PMID 42291136›Full record

ArticleMolecular therapy. Oncology2026

SIRPα ablated iPSC-derived macrophages resist hypophagia and enhance mAb-dependent and CAR-mediated cytotoxicity of solid tumors.

Portia R Smith, Md Ehsanul Kabir, Jue Zhang, John P Maufort, Matthew H Forsberg, Divine M Sedzro, Mark Berres, James A Thomson, Christian M Capitini, Igor I Slukvin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Portia R SmithWisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Md Ehsanul KabirWisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Jue ZhangMorgridge Institute for Research, Madison, WI 53715, USA.
John P MaufortWisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Matthew H ForsbergDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Divine M SedzroWisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Mark BerresBioinformatics Resource Center, University of Wisconsin, Madison, WI 53715, USA.
James A ThomsonMorgridge Institute for Research, Madison, WI 53715, USA.
Christian M CapitiniDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Igor I SlukvinWisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Transplantation of MHC Homozygous Vascular Progenitors in PrimatesU01HL134655 · NHLBI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI SLUKVIN, IGOR I. · 2016 to 2022
$7.7M
Molecular Determinants of Hemogenic EndotheliumR01HL142665 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SLUKVIN, IGOR I. · 2018 to 2021
$2.0M
NCI NIH HHS P30 CA014520NHLBI NIH HHS R01 HL142665NHLBI NIH HHS U01 HL134655NIH HHS P51 OD011106
6 · The paper itself

Abstract

The SIRPα-CD47 "don't eat me" checkpoint axis plays a critical role in shaping antitumor activities of macrophages within the tumor microenvironment (TME). However, targeting this axis with anti-CD47 antibodies to enhance antitumor responses in clinical trials has been challenging. Here, we demonstrated that

Indexed as

CAR macrophagesCD47/SIRPalphachimeric antigen receptorsCRISPR-Cas9exhaustionimmunotherapyiPSCsmacrophagesphagocytosissolid tumors

Identifiers

PMID42291136
PMCPMC13264185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.