Introducing azobenzenes as solid phase peptide synthesis linkers.

Connor B Śmieja, Lizun Xin, Tianhui Tang, Ryan Tan, Martin Lee, Alison N Hulme

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Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Connor B ŚmiejaEaStCHEM School of Chemistry, University of Edinburgh David Brewster Rd Edinburgh EH9 3FJ UK Alison.Hulme@ed.ac.uk.ORCID https://orcid.org/0000-0002-6662-6570

Lizun XinEaStCHEM School of Chemistry, University of Edinburgh David Brewster Rd Edinburgh EH9 3FJ UK Alison.Hulme@ed.ac.uk.ORCID https://orcid.org/0009-0004-1385-4408

Tianhui TangEaStCHEM School of Chemistry, University of Edinburgh David Brewster Rd Edinburgh EH9 3FJ UK Alison.Hulme@ed.ac.uk.

Ryan TanEaStCHEM School of Chemistry, University of Edinburgh David Brewster Rd Edinburgh EH9 3FJ UK Alison.Hulme@ed.ac.uk.

Martin LeeCancer Research UK Scotland Centre (Edinburgh), Institute of Genetics and Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK.ORCID https://orcid.org/0000-0001-6529-5784

Alison N HulmeEaStCHEM School of Chemistry, University of Edinburgh David Brewster Rd Edinburgh EH9 3FJ UK Alison.Hulme@ed.ac.uk.ORCID https://orcid.org/0000-0002-4619-1506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthogonally cleavable linkers are essential tools in solid-phase peptide synthesis (SPPS). We present a fluorogenic C̲o̲umarin-L̲oaded A̲z̲obenzene (COLAZ) linker for SPPS, which offers base and acid stability and a mild reductive cleavage. We synthesise model peptide WHISKEY with an integrated coumarin label using COLAZ resin and demonstrate that COLAZ and Rink linker technologies may be combined to produce peptides with a latent fluorophore. The biological compatibility of the COLAZ unit is demonstrated

Identifiers

PMID42291134

DOI10.1039/d6cb00028b

PMCPMC13255771

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LicenceCC BY

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