Evidence map›Paper›PMID 42291132›Full record

ArticleRSC chemical biology2026

Freya Spain, Diana Gimenez, Amanda M Acevedo-Jake, Bram Mylemans, Nikolas J Brooks, Boguslawa Korona, Danny T Huang, Thomas A Edwards, Aneika C Leney, Laura Itzhaki and 2 more

Abstract read
In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Freya SpainSchool of Chemistry, University of Birmingham Edgbaston B15 2TT UK a.j.wilson.1@bham.ac.uk.
Diana GimenezSchool of Chemistry, University of Birmingham Edgbaston B15 2TT UK a.j.wilson.1@bham.ac.uk.
Amanda M Acevedo-JakeSchool of Chemistry, University of Birmingham Edgbaston B15 2TT UK a.j.wilson.1@bham.ac.uk.ORCID https://orcid.org/0000-0002-4565-9453
Bram MylemansSchool of Chemistry, University of Bristol, Cantock's Close Bristol BS8 1TS UK.
Nikolas J BrooksSchool of Biosciences, University of Birmingham Edgbaston B15 2TT UK.ORCID https://orcid.org/0009-0009-7847-4947
Boguslawa KoronaDepartment of Pharmacology, University of Cambridge Cambridge CB2 1PD UK lsi10@cam.ac.uk.
Danny T HuangCancer Research UK Scotland Institute, Garscube Estate, Switchback Road Glasgow G61 1BD UK.ORCID https://orcid.org/0000-0002-6192-259X
Thomas A EdwardsCollege of Biomedical Sciences, Larkin University 18301 N Miami Ave #1 Miami Florida 33169 USA.ORCID https://orcid.org/0000-0002-1467-3674
Aneika C LeneySchool of Biosciences, University of Birmingham Edgbaston B15 2TT UK.ORCID https://orcid.org/0000-0002-2066-4950
Laura ItzhakiDepartment of Pharmacology, University of Cambridge Cambridge CB2 1PD UK lsi10@cam.ac.uk.ORCID https://orcid.org/0000-0001-6504-2576
Derek N WoolfsonSchool of Chemistry, University of Bristol, Cantock's Close Bristol BS8 1TS UK.ORCID https://orcid.org/0000-0002-0394-3202
Andrew J WilsonSchool of Chemistry, University of Birmingham Edgbaston B15 2TT UK a.j.wilson.1@bham.ac.uk.ORCID https://orcid.org/0000-0001-9852-6366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of protein-protein interactions (PPIs) plays a key role in disease progression. PPI interfaces have long been considered challenging targets to drug due to their large surface areas and lack of well-defined binding sites suitable for small molecules. Peptide-based ligands offer the opportunity to mimic the action of a native binding partner to inhibit PPIs. Previously, we have used the extensively characterized

Identifiers

PMID42291132
PMCPMC13256098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.