Evidence map›Paper›PMID 42291083›Full record

ArticleAmerican journal of preventive cardiology2026

Body mass index and waist-hip ratio - Risk factors for aortic valve disease: The atherosclerosis risk in communities (ARIC) study.

Chunxiao Zhang, Ethan Moser, Anne Eaton, Jeremy Van't Hof, Weihong Tang, Amil Shah, Aaron R Folsom, Lin Yee Chen

Abstract read
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In one paragraph

Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chunxiao ZhangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Ethan MoserDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Anne EatonDivision of Biostatistics & Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Jeremy Van't HofCardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Amil ShahDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Lin Yee ChenCardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA.

Funding

Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Mentoring patient-oriented research in deep phenotyping of cardiac function for heart failure preventionK24HL152008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAH, AMIL M · 2020 to 2024
$608k
NHLBI NIH HHS K24 HL152008NHLBI NIH HHS R01 HL135008
6 · The paper itself

Abstract

Background: Elevated body mass index (BMI) has been associated with increased risk of aortic valve stenosis (AS) in observational and Mendelian randomization studies; however, its association, and that of waist-hip ratio (WHR), with aortic valve insufficiency (AI) remains unclear. We investigated the association of BMI and WHR with incident aortic valve disease (AVD) in the ARIC Study. Methods: We analyzed ARIC participants with echocardiograms at Visits 5 (2011-13) and 7 (2018-19). BMI and WHR were assessed at Visit 5. Incident AVD between Visits 5 and 7 was categorized as aortic valve sclerosis, AI without stenosis, and AS. Multinomial regression models were employed. Results: Among 1931 participants (mean age of 73.5 ± 4.2 years, 59.7% female, and 23.2% Black), 572 (29.6%) developed AVD (345 aortic valve sclerosis, 159 AI, and 68 AS). Higher BMI was associated with a greater incidence of aortic valve sclerosis (OR: 1.29 per 1-SD (5.08 kg/m2), 95% CI: 1.13-1.48) and AS (OR: 1.28, 95% CI: 1.00-1.63), but not AI (OR: 0.93, 95% CI: 0.75-1.14). Higher WHR was associated with an increased risk of incident aortic valve sclerosis (OR: 1.17 per 1-SD (0.079), 95% CI: 1.00-1.35), AS (OR: 1.44, 95% CI: 1.11-1.85), and also AI (OR: 1.24, 95% CI: 1.01-1.53). Conclusions: Higher BMI is a risk factor for incident aortic valve sclerosis and AS, but not AI. Greater WHR is a risk factor not only for incident aortic valve sclerosis and AS, but also for incident AI. Avoiding abdominal obesity may prevent non-rheumatic AVD in older adults.

Indexed as

Abdominal obesityAortic valve diseaseAortic valve insufficiencyAortic valve sclerosisAortic valve stenosisBody mass indexWaist-hip ratio

Identifiers

PMID42291083
PMCPMC13261274

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.