Evidence map›Paper›PMID 42291082›Full record

ArticleAmerican journal of preventive cardiology2026

Association of high-sensitivity cardiac troponin T with all-cause and cardiovascular mortality in a mobile cohort of older adults aged 70 to 95 years - Results from the AugUR study.

Klaus J Stark, Martina E Zimmermann, Janina M Herold, Caroline Brandl, Ralph Burkhardt, Lars S Maier, Andreas Luchner, Maria A Heinrich, Iris M Heid, Alexander Dietl

Abstract read
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Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Klaus J StarkDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Martina E ZimmermannDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Janina M HeroldDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Caroline BrandlDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Ralph BurkhardtInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Lars S MaierDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Andreas LuchnerDepartment of Cardiology, Hospital Barmherzige Brueder Regensburg, Regensburg, Germany.
Maria A HeinrichDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Alexander DietlDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It remains unclear whether high-sensitivity cardiac troponin T (hsTnT) independently predicts mortality in older adults. Objective: To estimate mortality rate and association of hsTnT with all-cause and cardiovascular death in the older, mobile population. Methods: This analysis was conducted in 2055 subjects of the AugUR-study, a prospective population-based cohort study in individuals aged 70 years and older with up to 10-year mortality follow-up. We used Cox proportional hazard models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for association of hsTnT with all-cause, cardiovascular, non-cardiovascular and premature mortality risk. Association results of hsTnT with mortality were reported for tertiles and per 1 standard deviation (SD) of log-transformed values. Results: Participants were 70 to 95 years old with 48% men and 56% with prevalent cardiovascular disease (CVD). In a median follow-up period of 6.0 years, 385 (113 cardiovascular) deaths were recorded. For all-cause mortality, HR was 1.66 [95%CI=1.49-1.85] after adjustment for age and sex (p-value<0.001). For cardiovascular mortality, the effect was more pronounced (HR=2.17 [95%CI=1.79-2.63]; Conclusion: Elevated levels of hsTnT were associated with increased cardiovascular and non-cardiovascular mortality risk in an old-aged population. Measurement of hsTnT in subjects with prevalent CVD may help identify individuals at high risk for mortality.

Indexed as

AugURhigh-sensitivity cardiac troponin TMortalityOlder adultsPopulation-based studyRisk factors

Identifiers

PMID42291082
PMCPMC13261262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.