Evidence map›Paper›PMID 42291079›Full record

ArticleAmerican journal of preventive cardiology2026

Screening for high coronary plaque volume in primary prevention: integration of multi-omics and coronary calcium scoring into cardiovascular risk assessment.

Cheng Hwee Soh, Shaun Khanna, Jingqin Wu, Prasanna Venkataraman, Corey Giles, Nitesh Nerlekar, Melinda Carrington, Gerald F Watts, Stephen J Nicholls, Peter Meikle and 1 more

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Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Cheng Hwee SohBaker Heart and Diabetes Institute, Melbourne, Australia.
Shaun KhannaThe George Institute for Global Health, UNSW, Sydney, Australia.
Jingqin WuBaker Heart and Diabetes Institute, Melbourne, Australia.
Prasanna VenkataramanBaker Heart and Diabetes Institute, Melbourne, Australia.
Corey GilesBaker Heart and Diabetes Institute, Melbourne, Australia.
Nitesh NerlekarBaker Heart and Diabetes Institute, Melbourne, Australia.
Melinda CarringtonBaker Heart and Diabetes Institute, Melbourne, Australia.
Gerald F WattsRoyal Perth Hospital and School of Medicine, University of Western Australia, Perth, Australia.
Stephen J NichollsVictorian Heart Institute, Monash University, Melbourne, Australia.
Peter MeikleBaker Heart and Diabetes Institute, Melbourne, Australia.
Thomas H MarwickBaker Heart and Diabetes Institute, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atherosclerotic plaque volume (PV) predicts future cardiovascular events. As coronary computed tomography angiography (CCTA) is unsuitable for population screening, individuals with high total (T)PV often remain undetected. Objective: To evaluate the relative and incremental contributions of lipidomic risk score (LRS), polygenic risk score (PRS), and coronary artery calcium score (CAC) improves screening for high TPV. Methods: Primary prevention participants in two trials underwent clinical assessment, CAC, and blood sampling for LRS and PRS. CCTA was obtained in participants with CAC>0 and ≤400. Associations between risk scores and TPV were assessed using linear regression. Logistic regression identified predictors of high TPV; model performance was evaluated using area under the curve (AUC), net reclassification index (NRI), and integrated discrimination index (IDI). Results: In the development cohort ( Conclusion: CAC was the dominant determinant of high coronary plaque volume and accounted for the majority of predictive performance. LRS and PRS provided only modest incremental value beyond CAC and clinical risk, supporting their role as complementary rather than primary screening tools.

Indexed as

Cardiac imagingCoronary artery calcium scoreCoronary computed tomography angiographyLipidomic risk scorePolygenic risk score

Identifiers

PMID42291079
PMCPMC13261162

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