Evidence map›Paper›PMID 42291032›Full record

ArticleAmerican journal of preventive cardiology2026

Deep learning-derived pericardial adipose tissue by electrocardiogram-gated cardiac computed tomography predicts cardiovascular events beyond coronary calcium score.

Zahra Esmaeili, Jose R Medina-Inojosa, Elham Mahmoudi, Laura M Ortega-Aviles, Betsy J Medina-Inojosa, Bradley J Erickson, Francisco Lopez-Jimenez

Abstract read
In one paragraph

Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zahra EsmaeiliDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Jose R Medina-InojosaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Elham MahmoudiDepartment of Radiology, Radiology Informatics Lab, Mayo Clinic, Rochester, MN, USA.
Laura M Ortega-AvilesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Betsy J Medina-InojosaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Bradley J EricksonDepartment of Radiology, Radiology Informatics Lab, Mayo Clinic, Rochester, MN, USA.
Francisco Lopez-JimenezDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

Background: Pericardial adipose tissue (PAT) is an emerging imaging biomarker of cardiovascular disease (CVD) risk. We evaluated whether PAT volume improves prediction of cardiovascular events beyond Coronary Artery Calcium (CAC) score and the AHA Predicting Risk of Cardiovascular Disease Events (PREVENT™) equation. Methods: We analyzed data of 11,897 Olmsted County, MN, residents without known history of heart failure and atherosclerotic cardiovascular disease (ASCVD) events who underwent non-contrast, ECG-gated CAC scans. PAT volume (cm Results: Over a median of 16.4 years, 9.6% experienced total CVD events. Kaplan-Meier curves demonstrated progressively lower CVD-free survival across PAT and CAC groups (p < 0.001). PAT volume stratified risk across CAC categories, with higher volume conferring incremental risk even at low CAC (HR = 1.24, 95% CI:1.05-1.48), and enhanced risk stratification within borderline and intermediate PREVENT™ categories. Conclusion: PAT volume provides prognostic value for total CVD events beyond PREVENT™ and CAC scoring.

Indexed as

Agatston scoreCardiovascular disease eventsCoronary artery calcium scanDeep learningPericardial adipose tissuePericardial fat volumePREVENT™ risk score

Identifiers

PMID42291032
PMCPMC13261279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.