Evidence map›Paper›PMID 42290976›Full record

ArticleBioactive materials2026

Atomic-scale ordering enables intrinsic bioactivity and rapid osseointegration in medium-entropy alloys.

Jiahao Li, Meiyuan Jiao, Haoyang Li, Chenglong Li, Jiansong Zhang, Hui Wang, Jianchao Xue, Xiaoye Zhou, Honghui Wu, Qingfeng Yin and 6 more

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Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Jiahao LiDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Meiyuan JiaoBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Haoyang LiBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Chenglong LiBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Jiansong ZhangShenyang Medical College, Shenyang, 110034, China.
Hui WangBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Jianchao XueDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Xiaoye ZhouDepartment of Materials Science and Engineering, Shenzhen MSU-BIT University, Shenzhen, 518172, China.
Honghui WuInstitute for Carbon Neutrality, University of Science and Technology Beijing, Beijing, 100083, China.
Qingfeng YinBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Xiaomin TongDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Xin SuDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Yuan WuBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Jingjing TianBiomedical Engineering Facility of National Infrastructures for Translational Medicine, Institute of Clinical Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Zhaoping LuBeijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, University of Science and Technology, Beijing, 100083, China.
Yu ZhaoDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional alloys achieve mechanical reliability and corrosion resistance at the expense of bioactivity, necessitating exogenous surface treatments that introduce long-term interfacial instability. In this study, we demonstrate that atomic-scale ordering, specifically the coexistence of chemical short-range order (CSRO) and ordered oxygen complexes (OOCs), can intrinsically integrate these otherwise contradictory requirements within a single metallic system. This strategy exploits the principle that atomic arrangements governing bulk mechanical behavior concurrently regulate surface physicochemical properties, thereby eliminating the need for extrinsic modification. A Ti-30Zr-14Nb-3O medium-entropy alloy (MEA) designed with CSRO-OOCs synergy exhibits bone-matched elastic modulus (∼42 GPa) and high yield strength (∼1040 MPa), overcoming the conventional strength-modulus trade-off. Importantly, this atomic configuration intrinsically generates nanoscale surface roughness (Ra ∼50.80 nm) and optimized surface energy distribution-features typically achieved only through artificial surface engineering. These ordering-regulated surface characteristics promote accelerated osteogenic differentiation

Indexed as

BiocompatibilityChemical short-range orderMedium entropy alloysOrthopaedic implantsOsteoconductivity

Identifiers

PMID42290976
PMCPMC13253190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.