Evidence map›Paper›PMID 42290972›Full record

ArticleBioactive materials2026

Translation-driven design: development of an antibiotic-loaded hydrogel for the management of orthopaedic device-related infection.

Claudia Siverino, Lena Gens, Pamela Nylund, Andrew L Foster, Willemijn Boot, Dominic Gehweiler, Mats Bue, Stephan Zeiter, Andrea Montali, R Geoff Richards and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Claudia SiverinoAO Research Institute Davos, Davos-Platz, Switzerland.
Lena GensAO Research Institute Davos, Davos-Platz, Switzerland.
Pamela NylundAO Research Institute Davos, Davos-Platz, Switzerland.
Andrew L FosterAO Research Institute Davos, Davos-Platz, Switzerland.
Willemijn BootAO Research Institute Davos, Davos-Platz, Switzerland.
Dominic GehweilerAO Research Institute Davos, Davos-Platz, Switzerland.
Mats BueDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Stephan ZeiterAO Research Institute Davos, Davos-Platz, Switzerland.
Andrea MontaliAO Foundation - Innovation Center, Davos Platz, Switzerland.
R Geoff RichardsAO Research Institute Davos, Davos-Platz, Switzerland.
Matteo D'EsteAO Research Institute Davos, Davos-Platz, Switzerland.
T Fintan MoriartyAO Research Institute Davos, Davos-Platz, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthopedic device-related infection (ODRI) is a devastating complication, often requiring repeated revision surgeries and prolonged antibiotic treatment. Injectable biodegradable biomaterials that deliver and maintain high local concentrations of antibiotics to the surgical field may eliminate the need for additional surgeries while improving treatment outcomes. In this study, we introduce a Gel for Delivery of Antibiotics (GEDAI) for local administration of tobramycin (T), gentamicin (G) or gentamicin-vancomycin (GV). GEDAI was developed with translatability and ease of intraoperative handling as design goals. GEDAI displayed storage and loss moduli, shear thinning, and elastic recovery properties appropriate for intraoperative applications, with good adhesion to stainless steel and tissues but reduced adhesion to surgical gloves.

Indexed as

AntibioticAntimicrobialBiofilmDebridementFracture-related infection (FRI)GentamicinHydrogelIrrigation and implant retention (DAIR)MRSAMSSAOrthopedic-device related infection (ODRI)S. aureusSheep modelSingle stage revisionTobramycinVancomycin

Identifiers

PMID42290972
PMCPMC13264095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.