Evidence map›Paper›PMID 42290939›Full record

ReviewReproductive medicine and biology

International Expert Consensus Statement on Chronic Endometritis: A Comprehensive Literature Review and Modified e-Delphi Study.

Kotaro Kitaya, Keiji Kuroda, Seung Chik Jwa, Michio Kitajima, Masanori Ono, Iwaho Kikuchi, Tomoko Nakamura, Fumio Yamasaki, Kaori Koga, Tadahiro Yasuo and 30 more

Abstract readReview
In one paragraph

Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Kotaro KitayaThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.ORCID https://orcid.org/0000-0002-5693-3139
Keiji KurodaThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.
Seung Chik JwaThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.
Michio KitajimaThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.
Masanori OnoThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.
Iwaho KikuchiThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.ORCID https://orcid.org/0000-0003-4051-8165
Tomoko NakamuraThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.ORCID https://orcid.org/0000-0001-5987-4384
Fumio YamasakiThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.
Kaori KogaThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.
Tadahiro YasuoDepartment of Obstetrics and Gynecology Otsu City Hospital Otsu Japan.
Shunichiro TsujiDepartment of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan.
Fuminori KimuraDepartment of Obstetrics and Gynecology Nara Medical University Kashihara Japan.
Ayumu ItoDepartment of Obstetrics and Gynecology Faculty of Medicine, Toho University Tokyo Japan.ORCID https://orcid.org/0000-0002-9102-2322
Yasushi HirotaDepartment of Obstetrics and Gynecology Graduate School of Medicine, The University of Tokyo Tokyo Japan.
Mari NomiyamaWomen's Medical Center Takagi Hospital Okawa Japan.
Nanako IwamiKamiya Ladies Clinic Sapporo Japan.ORCID https://orcid.org/0000-0001-7262-7791
Kanako TakimotoKamiya Ladies Clinic Sapporo Japan.
Isao TakeharaDepartment of Obstetrics and Gynecology Faculty of Medicine, Yamagata University Yamagata Japan.
Yusuke SakoDepartment of Obstetrics and Gynecology St. Luke's International Hospital Tokyo Japan.
Kuniaki OtaDepartment of Obstetrics and Gynecology Kawasaki Medical School Kurashiki Japan.ORCID https://orcid.org/0000-0003-3984-975X
Lianghui DiaoShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital Shenzhen China.ORCID https://orcid.org/0000-0002-1159-9261
Yuye LiShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics and Gynecology Hospital Shenzhen China.ORCID https://orcid.org/0009-0008-3328-5002
Lei YanCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University Jinan Shandong China.ORCID https://orcid.org/0000-0001-6548-1317
Wei HuangDivision of Reproductive Medicine West China Second University Hospital of Sichuan University Chengdu China.
Shen ZhangLaboratory of Clinical Embryology, Reproductive Medicine Center, Department of Obstetrics and Gynecology The Second Affiliated Hospital, Chongqing Medical University Chongqing China.
Qiong WangDepartment of Obstetrics and Gynecology Reproductive Medical Center, First Affiliated Hospital of Sun Yat-Sen University Guangzhou China.
Fang GuDepartment of Obstetrics and Gynecology Reproductive Medical Center, First Affiliated Hospital of Sun Yat-Sen University Guangzhou China.
Jing ShuReproductive Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China.ORCID https://orcid.org/0000-0003-0398-2188
Mahvash ZargarFertility, Infertility and Perinatology Research Center, Department of Obstetrics and Gynecology Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Vitaly A KushnirDepartment of Obstetrics and Gynecology The University of California Irvine California USA.
Claudio BenadivaCenter for Advanced Reproductive Services Farmington Connecticut USA.
Constantin-Cristian VăduvaDepartment of Obstetrics and Gynecology Faculty of Medicine, University of Medicine and Pharmacy of Craiova Craiova Romania.ORCID https://orcid.org/0000-0001-7526-1756
Brecht GeysenberghZAS Augustinus Oosterveldlaan Wilrijk Belgium.
Orestis TsonisAssisted Conception Unit, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust London UK.
Tirso Pérez-MedinaHospital Universitario Puerta de Hierro Majadahonda Madrid Spain.
Inmaculada MorenoCarlos Simon Foundation, Valencia, Spain; INCLIVA Biomedical Research Institute Valencia Spain.ORCID https://orcid.org/0000-0001-6910-7509
Sergio HaimovichDepartment of Obstetrics and Gynecology at The Adelson Med School Ariel University Ariel Israel.
Amerigo VitaglianoUnit of Obstetrics and Gynaecology, Department of Interdisciplinary Medicine University of Bari "Aldo Moro", Policlinico of Bari Bari Italy.ORCID https://orcid.org/0000-0002-2824-5435
Ettore CicinelliUnit of Obstetrics and Gynaecology, Department of Interdisciplinary Medicine University of Bari "Aldo Moro", Policlinico of Bari Bari Italy.
Maki KusumiThe Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on Chronic Endometritis Tokyo Japan.ORCID https://orcid.org/0000-0002-7279-1986

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to develop international expert consensus statements on chronic endometritis (CE) through a comprehensive literature review of existing evidence and a modified Delphi approach. Methods: Ten panelists of the Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on CE performed a comprehensive review of the literature and derived statements with related comments on six specific domains of interest on CE. A two-round modified e-Delphi questionnaire was conducted among 31 international experts to evaluate the statements. Results: Twenty-three out of 24 statements, including 43 detailed items, on epidemiology (associated diseases and risk factors), symptomatology (asymptomatic or oligosymptomatic nature with subtle and nondescript gynecologic manifestations), etiology and pathogenesis (inflammation, infection, and clinical course), microbiology (associated pathogens), diagnosis (histopathology, immunohistochemistry, hysteroscopy, and microbiome analysis), and treatment (antibiotics, surgery, and multidrug resistance) finally reached a consensus. Notably, for the histopathologic diagnosis of CE, a threshold of ≥ 5 endometrial stromal plasma cells/10 high-power fields received an agreement rate of 81%. Conclusions: This comprehensive literature review and Delphi study provide a real-world clinical perspective on CE from diverse international experts. These consensus statements have the potential to lay a foundation for diagnostic criteria and/or clinical guidelines on CE.

Identifiers

PMID42290939
PMCPMC13263251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.