ArticleReproductive medicine and biology
Association Between Hysteroscopic Treatment of Cesarean Scar Disorder and Changes in the Endometrial Microbiome and Clinical Outcomes: A Prospective Observational Study.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Purpose: To evaluate the association between hysteroscopic treatment of cesarean scar disorder (CSDi), clinical improvement, and changes in the endometrial microbiome, as this remains unclear. Methods: This prospective observational study included 40 women diagnosed with symptomatic CSDi. Clinical outcomes, including symptom severity and ultrasonographic measurements, were assessed before and after hysteroscopic treatment. Endometrial microbiome analysis using 16S rRNA gene sequencing was performed in a predefined subgroup of 22 patients preoperatively and at 3 months postoperatively. Microbial composition and diversity were analyzed and correlated with clinical findings. Results: Hysteroscopic treatment resulted in a significant reduction in isthmocele dimensions and improvement in clinical symptoms across the entire cohort ( Conclusions: Hysteroscopic treatment of CSDi is associated with favorable clinical outcomes and concurrent alterations in the endometrial microbiome. Although microbiome analyses were performed in a subset of patients, the findings suggest a potential relationship between anatomical correction and microbial environment. Larger, controlled studies are warranted to further elucidate this association.
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