Evidence map›Paper›PMID 42290888›Full record

ArticleNeurology open access2026

Retinal Vessel Dysfunction in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: An Ultra-Widefield Fluorescein Angiography Study.

Yonatan Serlin, Colyn Munn, Elisa A Ferrante, Lyna Kamintsky, Chantal Cousineau-Krieger, Edmond J FitzGibbon, M Teresa Magone, Richard W J Lee, Tiarnán D L Keenan, Camilo Toro and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yonatan SerlinNeurophysiology of Epilepsy Unit, NINDS, National Institutes of Health, Bethesda, MD.
Colyn MunnSchool of Biomedical Engineering, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Elisa A FerranteNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Lyna KamintskyDepartment of Medical Neuroscience and the Brain Repair Center, Dalhousie University, Faculty of Medicine, Halifax, NS, Canada.
Chantal Cousineau-KriegerNational Eye Institute, National Institutes of Health, Bethesda, MD.
Edmond J FitzGibbonNational Eye Institute, National Institutes of Health, Bethesda, MD.
M Teresa MagoneNational Eye Institute, National Institutes of Health, Bethesda, MD.
Richard W J LeeNational Eye Institute, National Institutes of Health, Bethesda, MD.
Tiarnán D L KeenanNational Eye Institute, National Institutes of Health, Bethesda, MD.
Camilo ToroUndiagnosed Diseases Program, National Institutes of Health, Bethesda, MD.
Sherrell ApugoNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Alessandra BrofferioNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Beth A KozelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
M Luisa Iruela-ArispeDepartment of Cell and Development Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Alon FriedmanDepartment of Medical Neuroscience and the Brain Repair Center, Dalhousie University, Faculty of Medicine, Halifax, NS, Canada.
Manfred BoehmNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Funding

Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common inherited cerebral small vessel disease (cSVD), involves Methods: UW-FA was performed at baseline and after 13.9 ± 4.5 months. Retinal vessel permeability, blood flow, and perfusion across macular, mid-peripheral, and far-peripheral zones were quantified. Aberrant pixels exceeded healthy volunteer (HV) thresholds. Group differences, longitudinal changes, Results: Nineteen patients with genetically confirmed CADASIL (mean age 48.4 years; 52.6% female) and 9 matched HVs (mean age 44.3 years, 55.6% female) were included. Baseline far-peripheral permeability was higher in the CADASIL group vs HVs ( Discussion: Serial UW-FA scans detect progressive, region-specific retinal vessel dysfunction in a modest-sized cohort with CADASIL, potentially serving as a surrogate marker for cSVD progression.

Identifiers

PMID42290888
PMCPMC13262973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.