ArticleFrontiers in endocrinology2026
Association between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in POSEIDON Group 1 patients.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the relationship between serum progesterone (P) on the day of embryo transfer (ET) and pregnancy outcomes in patients classified as POSEIDON Group 1. Methods: This retrospective cohort study was conducted at the Reproductive Center of Yantai Yuhuangding Hospital between January 2016 and December 2023, enrolling 402 patients undergoing single or double ET on day 3 or day 5. Serum P and estradiol (E Results: The 10th and 90th percentiles of serum P on the day of ET were 9.45 ng/mL and 23.32 ng/mL, respectively. The clinical pregnancy rate was highest in the 9.45-23.32 ng/mL group and decreased significantly when serum P exceeded 23.32 ng/mL. After adjusting for confounders, multivariate logistic regression demonstrated that high serum P (≥23.32 ng/mL) was independently associated with a lower clinical pregnancy rate (adjusted OR = 1.454, 95% CI: 1.032-2.048, Conclusions: Serum P on the day of ET was significantly associated with clinical pregnancy rate in POSEIDON Group 1 patients, and BMI significantly modified this association. High serum P was linked to a lower clinical pregnancy rate in normal-weight patients, but not in overweight/obese patients. These findings support the implementation of individualized luteal support strategies based on serum P and BMI stratification.
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