ArticleFrontiers in veterinary science2026
Imaging diagnosis of Caroli-like disease with concurrent extrahepatic biliary obstruction in a young small-breed dog: case report.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Caroli-like disease is a rare congenital ductal plate malformation characterized by intrahepatic bile duct dilatation and has only rarely been reported in veterinary medicine. A 2-year-old castrated male small-breed dog (5.4 kg) was presented with jaundice, weight loss, and lethargy. Laboratory tests revealed elevated liver enzyme activities, hyperbilirubinemia, and coagulopathy. Radiography showed two mineralized opacities superimposed on the hepatic silhouette. Ultrasonography revealed cholecystolithiasis, gallbladder wall thickening, and biliary dilatation with choledocholithiasis, suggesting extrahepatic biliary obstruction. Computed tomography confirmed choledocholithiasis, diffuse biliary dilatation, and a 2- to 3-cm intrahepatic cystic structure containing calcified material and communicating with the intrahepatic bile ducts. Histopathological analysis revealed cholangiohepatitis with ductal proliferation, and immunohistochemical analysis confirmed the biliary epithelial origin of the lesion and supported a congenital ductal plate malformation. Despite surgical management, the patient died postoperatively. This case represents the first veterinary description of Caroli-like disease complicated by extrahepatic biliary obstruction in a young dog and highlights the fact that intrahepatic saccular dilatation may resemble gallbladder anomalies on ultrasonography, while computed tomography provides crucial diagnostic clarity. Recognition of such rare conditions may improve diagnostic accuracy and clinical decision-making in veterinary hepatobiliary disorders.
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